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Research Scientist, Translational Sciences

Primary Responsibility

Functional Focus: The Translational Sciences group aims to provide an in depth understanding of the mechanisms of tumour response to our SPEAR T-cell therapy.  We are looking for a driven individual to fully develop their skillset in order to understand and optimise responses to SPEAR-T cell therapy. Desirable skills include those related to histology and gene/protein expression profiling.

 

The purpose of this role is to primarily conduct scientific experiments as necessary within dedicated scientific and project teams.   Whilst initially requiring supervision by a more senior scientist, the job holder will develop further scientific skills to be able to work more independently on routine experiments.  The job holder will also be responsible for the interpretation of scientific results under the supervision of a Principal Scientist or Senior Scientist.

 

The scientist may also be involved in one or more support activities to enable the smooth running of the group or laboratory and enabling company functioning toward its goals (e.g. Lab steward role)

 

Performance in this role (including functional and project objectives and behaviours) is expected to be monitored through group performance and stakeholder feedback from peers, senior management and project team members (as outlined in the development framework for this position).

 

 

Key Responsibilities

  1. Conducting experiments and supporting colleagues, the group and Adaptimmune projects.
  2. In collaboration with the Senior Scientists and Principal Scientists, analyse, summarise and record experimental results and maintain relevant databases and records.
  3. Participate in group and project meetings and discussions.
  4. Routine lab maintenance.

 

Qualifications & Experience

Required:

  • Degree in Life Sciences (minimum B.Sc.)
  • Experience of laboratory procedures.
  • Ability to work independently on routine experiments with limited supervision.
  • Ability to learn and develop in order to work independently on more complex experiments within a reasonable time frame.

Desired :

  • Additional post-graduate scientific experience or qualifications, such as an MSc. or PhD

 

Skills & Competencies

Required

  • Histological skills including
    • FFPE Tissue sectioning using microtome,
    • Special stains (e.g.: Giemsa)
    • Immunohistochemistry
    • In situ hybridisation (e.g.: RNAscope)
  • Experience handling human tissue.
  • Ability to follow protocols.
  • Computer literate and ability to familiarise with different IT systems.
  • Excellent numeracy and English language skills (both written and verbal).
  • Excellent communication skills (both written and verbal).
  • Knowledge and skills to use of standard laboratory equipment (such as pipettes, pH meters, centrifuges).
  • Basic experimental design skills (use of controls, etc.) and attention to detail.
  • Good time management and organisational skills.
  • Able to work independently after training.
  • Strong team player but with the ability to work independently as well.

Desired

  • Use of Discovery Ultra Research Instrument (IHC and ISH Platform)
  • Analytical assay validation
  • Experience of immunology and/or cell biology
  • Understanding of Digital Pathology analysis (HALO)
  • Experience working under HTA licence.

 

 

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