Senior Scientist, Analytical Development

Cambridge, MA

Full Time

Analytical Development

Experienced

Adaptimmune is a fully integrated commercial-stage cell therapy company, designed and built from the ground up with UK- and U.S.-based biotechnology hub locations. In the U.S., locations are in Cambridge, MA and Philadelphia, PA. In the UK, locations are in Oxford and Stevenage. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.

Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.

This Senior Scientist will join the Analytical Development team to develop, optimize, and perform qualification/validation work on numerous analytical methods for early/late-stage cell therapy. Extensive experience with potency assays, molecular assays, flow cytometry, cell culture, and T cells is required. Experience in T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems would also be a plus.

Your primary responsibilities will include design and execution of experiments, and authorship of technical protocols and reports. Additional activities include method optimization and method qualification. This position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Key Responsibilities

Plan, design, conduct, analyze, interpret experiments mostly independently
Lead the development of assays for clinical and preclinical use
Design and execute qualification/validations of assays
Label and store samples
Maintain databases
Fully Analyze and write up results in electronic lab notebooks in a timely manner
Prepare documentation, including study plans, SOPs (protocols), batch records, experimental evaluation and summary, study reports, etc.
Proactively seek input from colleagues to progress own projects as well as actively share own experience and knowledge to help progress colleagues’ projects.
Contribute to routine lab maintenance as well as be considerate to colleagues, abiding by the lab rules and working in a safe, clean and tidy manner
If available and appropriate, project work-stream leadership/management and/or supervision and training of other junior scientists

Qualifications and Experience

Degree in biochemistry, chemical engineering, or related discipline
Substantial and relevant post-graduate experience within academic or industry setting, preferably including an MSc or PhD in a relevant scientific area
Extensive relevant experience of laboratory procedures, including cell culture and ideally flow cytometry or other vector-based analytical methods
Experience with developing and troubleshooting assays and ideally with evaluating assay performance
Experience in analytical assay development, and familiarity with regulatory guidelines around assay validation.

Desirable

An in depth understanding of immunology/T cell biology, cell-based assays (i.e. Potency), molecular assays, and flow cytometry
Experience working with lentiviral vectors and primary human T cells including T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
Experience working with quality systems

At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

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Senior Scientist, Analytical Development

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