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Scientist (T-cell Immunology)

Primary Responsibility

Adaptimmune are Seeking a highly motivated junior scientist with relevant industrial experience, and a good background in T cell immunology to join the dynamic Cell Research team at Adaptimmune. The Cell Research group is responsible for proposing and testing second generation T cell products for improvements in T cell product efficacy and persistence.  Desirable skills for this group include primary cell culture, lentiviral transfection, flow cytometry and cytotoxicity assays including, but not limited to Incucyte.

The successful candidate would have an MSc or BSc with relevant experience in T cell immunology to contribute to our dynamic, exciting culture that embraces teamwork and innovation. The purpose of this role is to primarily conduct scientific experiments as necessary within our dedicated scientific team.  You will work under the supervision of more experienced Senior and Principal scientists to contribute to the development of various next generation cellular therapies. You will also be required to interpret scientific results under the supervision of a senior scientist and to present your conclusions in group meetings.

Please note : Hep B Vaccination (with documentary evidence of successful vaccination titre) is preferably required for this position.  If not already vaccinated, Hepatitis B vaccination will be required and costs covered by Adaptimmune.

 

Key Responsibilities

  1. 70% the design and execution of T cell assays including but not limited to cytotoxicity, cytokine/chemokine measurements, and proliferation
  2. 25% data analysis and communication of conclusions
  3. 5% maintaining knowledge latest scientific literature relevant to cellular therapies, genetic engineering, and T cell biology

 

Qualifications & Experience

Required

  • MSc or BSc with relevant industrial experience in immunology

Desirable

  • Proficiency in the use of software to support data analysis such as FlowJo, FACSDiva, GraphPad Prism, as well as Microsoft Office (Excel, PowerPoint, Word, Outlook)

 

Skills & Competencies

Required

  • Multi-colour flow cytometry (knowledge of T cell subsets)
  • Mammalian cell culture
  • Primary T cell assays (expansion, proliferation and cytotoxicity)
  • Knowledge of the latest scientific literature relevant to cellular therapies, cell engineering, and T cell biology

Desirable

  • Prior experience with generation of retroviral/lentiviral vectors and transduction of target cells

 

 

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