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Scientist/Senior Scientist - Mass Spectrometry (12 month Contract)

Adaptimmune are looking for an enthusiastic, highly motivated individual to join our Mass Spectrometry Research Group.  The group is equipped with the very latest generation LC-MS/MS instruments and bioinformatics software and performs the critical role of target identification within Adaptimmune.

The Mass Spectrometry group are primarily focused on the development and application of mass spectrometry and proteomics based assays and data analyses procedures to identify new HLA targets for the company. In addition to this, the group will develop analytical approaches to support other functional groups within the company. This may include, but is not limited to, quantitative assays to determine protein expression and HLA presentation.

 

Key Responsibilities include:

  • Purification and identification of HLA peptides by mass spectrometry from cell lines and tumour tissues
  • Bioinformatic analyses of large, quantitative proteomics datasets
  • Communication of scientific findings to other research groups within Adaptimmune
  • Design, optimization and implementation of new mass spectrometry based assays
  • Accurate recording and reporting of experimental findings
  • Maintenance and operation of LC-MS/MS mass spectrometers

 

Experience Required

  1. Candidates should have a minimum of a PhD in Chemistry, Biochemistry, Proteomics, Mass Spectrometry or Molecular Biology, maybe with additional postdoctoral laboratory experience in academia or industry.
  2. Substantial and relevant post-graduate experience within a relevant scientific area.
  3. Extensive relevant experience of laboratory procedures.
  4. Ability to work independently on routine experiments
  5. Ideally candidates would have experience in  the following areas:
  • Quantitative proteomics and mass spectrometry of peptides and proteins using latest generation LC-MS/MS platforms and associated nano-flow HPLC systems
  • Protein biochemistry, with an emphasis on protein purification by immunoaffinity purification from tissue samples
  • Bioinformatic analyses of large datasets
  • Experience of data analysis relevant to mass spectrometry and proteomics

 

Hepatitis B vaccination may be required and costs covered by Adaptimmune if necessary.

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