A key focus is on in-process assays used to assist real-time rapid decisions in T-Cell process Development, that are applicable to the type and throughput of samples generated during (scale up / scale down) cell culture conditions used for process development experiments, including automated high-throughput. This focus distinguishes it from other analytics groups which may focus on end product (e.g. Q.C release assays), fundamental biology or prioritises different timescales. The assays will focus on suitable assays to inform both functionality of the T-cells and also their metabolism as impacted by changes implemented during T-cell bioprocess development.
Reporting to Lead T-Cell Process Analytics (Principle Scientist) the purpose of this role is to primarily conduct scientific experiments to support either the departmental objectives or company project objectives as necessary within dedicated scientific or project team.
The Senior Scientist will be relatively independent in both the conduct and analysis of their experiments but may still require scientific guidance at some level from the group/departmental/functional Principal Scientists. So that the analytics role is integrated into the process development team some level of matrixed accountability to the process development leaders will also be required
Depending on the requirement, availability and appropriateness (particularly regarding level within band) individuals in the Senior Scientist role may be involved in project work-stream leadership/management and/or supervision of other junior scientists or technicians. (Note. This will enable appropriate selection and training for future career paths).
Performance in this role (including functional and project objectives and behaviours) will be monitored through group performance and stakeholder feedback from peers, senior management and project team members (as outlined in the development framework for this position).
1 In partnership with the Principal Scientist, designing and conducting experiments to develop in-process assays relevant to T-cell therapy bioprocessing. Design, implement and interpret appropriate assays, including flow panels for high throughput in-process use, to inform process development of T-cells and assess the impact of process changes. Either directly perform the assays or supervise the assay performance by other scientists. A good understanding of the assay design, its robustness, interpretation of results and trouble shooting will be a key aspect of the role.
2 Work collaboratively with Cell Process Development project/work-stream leaders to co-facilitate projects. Act as Liaison with other analytical groups (e.g. Analytical Development, MS&T, QC and translational sciences), using process knowledge to facilitate productive interactions with analytical teams and vice-verse.
3 Analyse, summarise and record experimental results and interact with T-Cell Process Development team members to interpret analytics results in context of Process Development experiments in a timely manner. Take ownership for the assay design and quality of performance of the assay in the context of the process development experiment
4 Participate in group and project meetings and discussions.
5 Contribute to routine lab maintenance
6 If available and appropriate (pending level with band), project work-stream leadership/management and/or supervision of other junior scientists or technicians
Qualifications & Experience
Skills & Competencies
Decision Making Authority
Size and scope of team
Occasional overseas travel may be required (e.g. to external contractors or institutes) to deputise for the Lead T-cell Process analytics (Principle Scientist)