Senior Scientist, T-cell In-process Analytics

Primary Responsibility

A key focus is on in-process assays used to assist real-time rapid decisions in T-Cell process Development, that are applicable to the type and throughput of samples generated during (scale up / scale down) cell culture conditions used for process development experiments, including automated high-throughput. This focus distinguishes it from other analytics groups which may focus on end product (e.g. Q.C release assays), fundamental biology or prioritises different timescales. The assays will focus on suitable assays to inform both functionality of the T-cells and also their metabolism as impacted by changes implemented during T-cell bioprocess development.

Reporting to Lead T-Cell Process Analytics (Principle Scientist) the purpose of this role is to primarily conduct scientific experiments to support either the departmental objectives or company project objectives as necessary within dedicated scientific or project team. 

The Senior Scientist will be relatively independent in both the conduct and analysis of their experiments but may still require scientific guidance at some level from the group/departmental/functional Principal Scientists.  So that the analytics role is integrated into the process development team some level of matrixed accountability to the process development leaders will also be required

Depending on the requirement, availability and appropriateness (particularly regarding level within band) individuals in the Senior Scientist role may be involved in project work-stream leadership/management and/or supervision of other junior scientists or technicians. (Note. This will enable appropriate selection and training for future career paths).

Performance in this role (including functional and project objectives and behaviours) will be monitored through group performance and stakeholder feedback from peers, senior management and project team members (as outlined in the development framework for this position).

Key Responsibilities

1    In partnership with the Principal Scientist, designing and conducting experiments to develop in-process assays relevant to T-cell therapy bioprocessing.  Design, implement and interpret appropriate assays, including flow panels for high throughput in-process use, to inform process development of T-cells and assess the impact of process changes.  Either directly perform the assays or supervise the assay performance by other scientists. A good understanding of the assay design, its robustness, interpretation of results and trouble shooting will be a key aspect of the role.

2    Work collaboratively with Cell Process Development project/work-stream leaders to co-facilitate projects.  Act as Liaison with other analytical groups (e.g. Analytical Development, MS&T, QC and translational sciences), using process knowledge to facilitate productive interactions with analytical teams and vice-verse.

3    Analyse, summarise and record experimental results and interact with T-Cell Process Development team members to interpret analytics results in context of Process Development experiments in a timely manner.  Take ownership for the assay design and quality of performance of the assay in the context of the process development experiment

4    Participate in group and project meetings and discussions.

5    Contribute to routine lab maintenance

6    If available and appropriate (pending level with band), project work-stream leadership/management and/or supervision of other junior scientists or technicians

 

Qualifications & Experience

Required

  • Degree in Life Sciences, or related discipline.
  • Substantial and relevant post-graduate experience within academic or industry setting, preferably including an MSc or PhD in a relevant scientific area.
  • Extensive relevant experience of laboratory procedures, ideally including flow cytometry and other cell-based analytical methods ideally with some experience of developing, trouble shooting and evaluating robustness of assays.
  • Ability to work independently on routine experiments.
  • Ability to learn and develop in order to work independently on complex experiments within a reasonable time frame.

Desirable

  • An in depth understanding of the relevant scientific area
  • Experience of high throughput analytics and automation

 

Skills & Competencies

Required

  • Computer literate and ability to familiarise with different IT systems.
  • Excellent numeracy and English language skills (both written and verbal).
  • Excellent communication skills (both written and verbal).
  • Ability to follow protocols.
  • Knowledge and skills to use of standard laboratory equipment (such as pipettes, pH meters, centrifuges).
  • Ability to design experiments and studies to address key scientific questions.
  • High attention to detail, good time management skills and communication skills. 
  • Able to work independently after training.
  • Strong team player but with the ability to work independently as well.

Desirable

  • Familiarity with more specialist lab equipment.
  • Work-stream leadership and planning experience.
  • Exposure and some experience with people management.

 

Decision Making Authority

  • Day-to-day management of own experiments with input from Principal Scientist and Line Manager.

Size and scope of team

  • May supervise individual or a small team of scientists/technicians in a matrix environment.

Budget responsibility

  • May help compile budgetary requirements

Other Requirements

Occasional overseas travel may be required (e.g. to external contractors or institutes) to deputise for the Lead T-cell Process analytics (Principle Scientist)

 

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