Manager, External Manufacturing

Supply Chain, CMC - Remote - Full Time

Adaptimmune is a clinical-stage biopharmaceutical company focused on the development and commercialization of novel immunotherapy products for people with cancer. The Company's unique SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell platform enables the engineering of T-cells to target and destroy cancer across multiple solid tumors.

Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.

Primary Responsibility

Manager, External Manufacturing will assist in both internal and external coordination of Contract Manufacturing Organizations (CMOs) managed under the External Manufacturing team. This includes but is not limited to leading a matrix team (Virtual Site Team)  to align on internal objectives and communicate the outputs to an externally facing forum specific to each CMO. Timelines, budget, and overall project goals will be managed via VST, with the Manager of External Manufacturing determining when escalation is appropriate.
Negotiation and understanding of key contract terms is expected related to the work being performed at each CMO.

Key Responsibilities

Virtual Site Team Management
  • Lead and coordinate cross-functionally all ongoing and upcoming production or tech transfer activities at each CMO inclusive of cell drug product, viral vector, and plasmids manufacturing.
  • Establish business processes and cross-functional relationships with internal/external partners, including senior leaders at the CMO.
  • Assist with coordination of governance meetings, inclusive of operational through C-level steering committee
  • Maintain accessible record of VST decisions, timelines, and goals to ensure stakeholders are informed and held accountable to functionally appropriate tasks.
  • Act as internal and external escalation point for CMO-related discussions.
Relationship Building / External Coordination (CMO)
  • Develop strong relationships with both internal VST stakeholders and external operational CMO representatives
Contract Negotiation/Support and Invoice Management
  • Support contract negotiations.
  • Ensuring that all contractual obligations with our CMOs are met
  • Manage invoice tracking and timely approvals.
Key Metrics Management and Development
  • Develop and monitor key KPIs specific to each CMO with a monthly summary/output of the performance.
  • Support coordination of business review series at CMOs to review metrics/KPIs/overall health of business
Logistics Coordination
  • Ensure sufficient supply of ADAP-supplied materials via logistics requests
  • Support coordination of CMO discussions to align on timing and process for upcoming shipments
Front Line Support
  • Provide front-line support for process or equipment related issues at the CMO and ensure cross-functional engagement internally.
  • Drive the resolution of major and critical deviation investigations.
  • Partner with Process Development and Quality to tech transfer and qualify/ validate manufacturing processes and QC methods.
  • Other duties as assigned.
other requirements
  • Minimum at-home requirement of High Speed Internet to ensure ability to work remotely from home as required by business needs.
  • Preferably bi-weekly in the office ( in sync with team meetings or other key meetings )
  • Quiet and private work area while working remotely
  • Valid driver’s license
  • Ability to travel, estimated to be 20% on average.
  • Attend business reviews, as needed
  • Visit/tour CMO manufacturing space

At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

Apply: Manager, External Manufacturing
* Required fields
First name*
Last name*
Email address*
Location *
Phone number*
Resume*

Attach resume or Paste resume

Attach resume as .pdf, .doc, .docx, .odt, .txt, or .rtf (limit 5MB) or paste resume

Paste your resume here or attach resume file

By continuing with and submitting your application, you are agreeing to the following:

1. You have read and understood the statements made in the consent form and the ways in which your personal data will be stored and processed.
2. To the storing and processing of your personal information by Adaptimmune, members of the Adaptimmune group of companies and third parties working on behalf of Adaptimmune as set out in the consent form.
3. To the storing and processing of your personal information outside of the European Union and to the transfer of personal information between the EU and the United States.
4. To the storing of personal information for the periods set out in the Privacy Notice.
5. You understand that you can withdraw your consent at any time.*
Do you have the independent right to live and work in this country without the need for Visa sponsorship?*
Adaptimmune is committed to ensuring a safe, healthy and productive work environment. For certain categories of roles, including those that deal with patient materials or manufacturing equipment, or otherwise have reasons for additional requirements, all new hires must pass a standard background and drug screen. Adaptimmune prohibits the hiring of any candidate who fails the drug screen, including those with a marijuana medical card.
Can you meet this requirement??*
The following questions are entirely optional.
To comply with government Equal Employment Opportunity and/or Affirmative Action reporting regulations, we are requesting (but NOT requiring) that you enter this personal data. This information will not be used in connection with any employment decisions, and will be used solely as permitted by state and federal law. Your voluntary cooperation would be appreciated. Learn more.
Gender
Race/Ethnicity
Invitation for Job Applicants to Self-Identify as a U.S. Veteran
  • A “disabled veteran” is one of the following:
    • a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or
    • a person who was discharged or released from active duty because of a service-connected disability.
  • A “recently separated veteran” means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
  • An “active duty wartime or campaign badge veteran” means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.
  • An “Armed forces service medal veteran” means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
Veteran status
I IDENTIFY AS ONE OR MORE OF THE CLASSIFICATIONS OF PROTECTED VETERAN LISTED ABOVE
I AM NOT A PROTECTED VETERAN
I DON’T WISH TO ANSWER
Voluntary Self-Identification of Disability
Voluntary Self-Identification of Disability Form CC-305
OMB Control Number 1250-0005
Expires 04/30/2026
Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Please check one of the boxes below:
YES, I HAVE A DISABILITY, OR HAVE HAD ONE IN THE PAST
NO, I DO NOT HAVE A DISABILITY AND HAVE NOT HAD ONE IN THE PAST
I DO NOT WANT TO ANSWER

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Name Date
Human Check*