Sr. Scientist, in vivo Pharmacology
Research - Cambridge, MA - Full Time
Adaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.
Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.
This role is located at our Cambridge, Massachusetts site, in the heart of Kendall Square.
Primary Responsibility
We are seeking a Senior Scientist, in vivo Pharmacology who will report to the Director of Pre-Clinical R&D.
The successful candidate will be an experienced in vivo Pharmacologist with experience in cancer immunotherapy who will supervise IND-enabling studies for TRuC and TCR-T cell development candidates. The ideal applicant will have extensive hands-on experience with human tumor xenograft, syngeneic, and humanized mouse model development and experience in moving preclinical candidates from early discovery to IND. The qualified candidate may supervise or directly manage the execution of IND-enabling in vivo studies for TRuC and TCR-T cell development candidates, prepare technical reports, and complete submission-ready documents for regulatory filings (pre-IND, IND, etc).
Key Responsibilities
- Oversee design and execution of in vivo pharmacology studies in support of regulatory filings.
- Lead hands-on from the bench to guide, train and coach a small scientific team.
- Ensure data is captured in appropriate databases and in electronic laboratory notebooks.
- Supervise pharmacology studies for appropriate conduct, accuracy, and execution; audit raw data for accuracy, prepare and review draft reports; finalize reports as submission-ready documents for regulatory authorities.
- Review and contribute to authoring of pharmacology sections of regulatory documents and ensure their quality and accuracy.
- Serve as In Vivo Pharmacology lead on project teams by executing experimental and strategic study design, interpreting data independently, and preparing data presentations for program and company meetings.
- Work effectively with other disciplines, including translational science and our pre-clinical team in the UK, to build the preclinical data package for clinical candidate nomination.
Qualifications & Experience
Required
- PhD* in Biology-related discipline. Preferred 5+ years post-PhD research experience, in the in vivo evaluation of cancer immunotherapies; 2+ years of industry experience with adoptive immunotherapies
- Experience with xenogeneic and syngeneic mouse tumor models and humanized mouse models to evaluate efficacy, mechanism of action, dose response and biodistribution are highly desirable.
- Proficiency and hands-on experience in technical skills to carry out efficacy, pharmacokinetic and biodistribution studies in xenogeneic rodent tumor models.
- Experience in immuno-oncology and/or T cell therapeutics is helpful.
- Experience working with cross-functional teams.
- History of moving product candidates through preclinical studies to IND is desirable.
- Able to prepare technical reports, drafting pharmacology sections of IND, providing documents for regulatory filings.
- Demonstrated commitment to quality, excellent attention to detail, experience managing in vivo electronic databases and data capture in electronic laboratory notebooks.
- Excellent oral and written communication skills
- Ability to clearly communicate to Project teams and senior management.
*Candidates without a Ph.D. may be considered if they have commensurate experience
At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.
