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Scientist/Senior Scientist (T-cell Immunology) - Maternity cover (12mths contract)

Primary Responsibility

Adaptimmune are seeking a highly motivated, recently qualified PhD with a good background in T cell immunology to join the dynamic Cell Research team at Adaptimmune. The Cell Research group is responsible for proposing and testing second generation T cell products for improvements in T cell product efficacy and persistence.  The required skills to perform the role include primary cell culture, lentiviral transfection, ELISA, flow cytometry and cytotoxicity assays including, but not limited to Incucyte.

The successful candidate would have a PhD in T cell immunology and contribute to our dynamic, exciting culture that embraces teamwork and innovation. The purpose of this role is to primarily conduct research projects independently or with other senior scientists, as necessary, within our dedicated scientific team.  You will work initially under the supervision of more experienced Senior and Principal scientists to contribute to the development of various next generation cellular therapies. You will also be required to interpret scientific results, present your conclusions and strategies for future work in group meetings.

Please note : Hep B Vaccination (with documentary evidence of successful vaccination titre) is required for this position.

 

Key Responsibilities

  1. 60% the design and execution of T cell assays including but not limited to cytotoxicity, proliferation cytokine/chemokine measurements and flow cytometry
  2. 30% data analysis and communication of conclusions
  3. 10% maintaining knowledge latest scientific literature relevant to cellular therapies, genetic engineering, and T cell biology

 

Qualifications & Experience

Required

  • PhD with relevant experience in T cell immunology
  • Proficiency in the use of software to support data analysis such as FlowJo, FACSDiva, GraphPad Prism, as well as Microsoft Office (Excel, PowerPoint, Word, Outlook)
  • Hep B Vaccination

 

Skills & Competencies

Required

  • Multi-colour flow cytometry (knowledge of T cell subsets)
  • Soluble mediator detection assays (ELISA, MAGPIX, MSD)
  • Mammalian cell culture
  • Primary T cell assays (expansion, proliferation and cytotoxicity)
  • Generation of retroviral/lentiviral vectors and transduction of target cells
  • Knowledge of the latest scientific literature relevant to cellular therapies, cell engineering, and T cell biology

 

 

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